EC 2.5.1.39 - 4-hydroxybenzoate polyprenyltransferase

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IntEnz Enzyme Nomenclature
EC 2.5.1.39

Names

Accepted name:
4-hydroxybenzoate polyprenyltransferase
Other names:
4-hydroxybenzoate transferase
p-hydroxybenzoate dimethylallyltransferase
p-hydroxybenzoate polyprenyltransferase
p-hydroxybenzoic acid-polyprenyl transferase
p-hydroxybenzoic-polyprenyl transferase
nonaprenyl-4-hydroxybenzoate transferase
4-hydroxybenzoate nonaprenyltransferase
Systematic name:
polyprenyl-diphosphate:4-hydroxybenzoate polyprenyltransferase

Reactions

Comments:

This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency [2,4,5].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00727
Structural data: CSA , EC2PDB
Gene Ontology: GO:0002083 , GO:0047293
CAS Registry Number: 9030-77-7
UniProtKB/Swiss-Prot: (12) [show] [UniProt]

References

  1. Kalén, A., Appelkvist, E.-L., Chojnacki, T. and Dallner, G.
    Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver.
    J. Biol. Chem. 265: 1158-1164 (1990). [PMID: 2295606]
  2. Melzer, M., Heide, L.
    Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli.
    Biochim. Biophys. Acta 1212: 93-102 (1994). [PMID: 8155731]
  3. Okada, K., Ohara, K., Yazaki, K., Nozaki, K., Uchida, N., Kawamukai, M., Nojiri, H., Yamane, H.
    The AtPPT1 gene encoding 4-hydroxybenzoate polyprenyl diphosphate transferase in ubiquinone biosynthesis is required for embryo development in Arabidopsis thaliana.
    Plant Mol. Biol. 55: 567-577 (2004). [PMID: 15604701]
  4. Forsgren, M., Attersand, A., Lake, S., Grunler, J., Swiezewska, E., Dallner, G., Climent, I.
    Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ.
    Biochem. J. 382: 519-526 (2004). [PMID: 15153069]
  5. Tran, U. C., Clarke, C. F.
    Endogenous synthesis of coenzyme Q in eukaryotes.
    Mitochondrion 7: S62-S71 (2007). [PMID: 17482885]

[EC 2.5.1.39 created 1992, modified 2010]