EC 2.4.2.8 - Hypoxanthine phosphoribosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.2.8

Names

Accepted name:
hypoxanthine phosphoribosyltransferase
Other names:
6-hydroxypurine phosphoribosyltransferase
6-mercaptopurine phosphoribosyltransferase
GMP pyrophosphorylase
GPRT
HGPRTase
HPRT
IMP pyrophosphorylase
IMP-GMP pyrophosphorylase
guanine phosphoribosyltransferase
guanine-hypoxanthine phosphoribosyltransferase
guanosine 5'-phosphate pyrophosphorylase
guanosine phosphoribosyltransferase
guanylate pyrophosphorylase
guanylic pyrophosphorylase
hypoxanthine-guanine phosphoribosyltransferase
inosinate pyrophosphorylase
inosine 5'-phosphate pyrophosphorylase
inosinic acid pyrophosphorylase
inosinic pyrophosphorylase
purine-6-thiol phosphoribosyltransferase
transphosphoribosidase
Systematic name:
IMP:diphosphate phospho-D-ribosyltransferase

Reactions

Comments:

Guanine and 6-mercaptopurine can replace hypoxanthine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00096
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052657 , GO:0004422
CAS Registry Number: 9016-12-0
UniProtKB/Swiss-Prot: (102) [show] [UniProt]

References

  1. Flaks, J.G.
    Nucleotide synthesis from 5-phosphoribosylpyrophosphate.
    Methods Enzymol. 6: 136-158 (1963).
  2. Kornberg, A., Lieberman, I. and Simms, E.S.
    Enzymatic synthesis of purine nucleotides.
    J. Biol. Chem. 215: 417-427 (1955).
  3. Lukens, L.N. and Herrington, K.A.
    Enzymic formation of 6-mercaptopurine ribotide.
    Biochim. Biophys. Acta 24: 432-433 (1957).
  4. Remy, C.N., Remy, W.T. and Buchanan, J.M.
    Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of α-5-phosphoribosylpyrophosphate.
    J. Biol. Chem. 217: 885-895 (1955).

[EC 2.4.2.8 created 1961, modified 1982]