EC 2.4.2.30 - NAD+ ADP-ribosyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.2.30

Names

Accepted name:
NAD+ ADP-ribosyltransferase
Other names:
ADP-ribosyltransferase (polymerizing)
poly(ADP-ribose) synthase
poly(ADP-ribose)polymerase
poly(ADP-ribose) synthetase
poly(adenosine diphosphate ribose) polymerase
NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase [incorrect]
NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase
Systematic name:
NAD+:poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase

Reaction

Comments:

The ADP-D-ribosyl group of NAD+ is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00360 , PROSITE:PDOC51059
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003950
CAS Registry Number: 58319-92-9
UniProtKB/Swiss-Prot: (57) [show] [UniProt]

References

  1. Ueda, K. and Hayaishi, O.
    ADP-ribosylation.
    Annu. Rev. Biochem. 54: 73-100 (1985). [PMID: 3927821]
  2. Ueda, K., Kawaichi, M. and Hayaishi, O.
    Poly(ADP-ribose) synthetase.
    In: Hayaishi, O. and Ueda, K. (Eds.) ADP-Ribosylation Reactions: Biology and Medicine, Academic Press, London, 1982, 117-155
  3. Ushiro, H., Yokoyama, Y. and Shizuta, Y.
    Purification and characterization of poly (ADP-ribose) synthetase from human placenta.
    J. Biol. Chem. 262: 2352-2357 (1987). [PMID: 2434482]

[EC 2.4.2.30 created 1984, modified 1990]