EC 2.4.2.3 - Uridine phosphorylase

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IntEnz Enzyme Nomenclature
EC 2.4.2.3

Names

Accepted name:
uridine phosphorylase
Other names:
UPH
UPase
UrdPase
pyrimidine phosphorylase
Systematic name:
uridine:phosphate α-D-ribosyltransferase

Reaction

Comments:

The enzyme participates the the pathways of pyrimidine ribonucleosides degradation and salvage. The mammalian enzyme also accepts 2'-deoxyuridine. Formerly EC 2.4.2.23.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00946
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004850
CAS Registry Number: 9030-22-2
UniProtKB/Swiss-Prot: (198) [show] [UniProt]

References

  1. Canellakis, E.S.
    Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism.
    J. Biol. Chem. 227: 329-338 (1957).
  2. Paege, L.M. and Schlenk, F.
    Bacterial uracil riboside phosphorylase.
    Arch. Biochem. Biophys. 40: 42-49 (1952).
  3. Pontis, H., Degerstedt, G. and Reichard, P.
    Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor.
    Biochim. Biophys. Acta 51: 138-147 (1961).

[EC 2.4.2.3 created 1961]