EC - Dolichyl-phosphate β-D-mannosyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
dolichyl-phosphate β-D-mannosyltransferase
Other names:
GDP-mannose-dolichol phosphate mannosyltransferase
GDPMan:DolP mannosyltransferase
GDPmannose-dolichylmonophosphate mannosyltransferase
GDPmannose:dolichyl-phosphate mannosyltransferase
dolichol phosphate mannose synthase
dolichyl mannosyl phosphate synthase
dolichyl phosphate mannosyltransferase
dolichyl-phosphate mannose synthase
dolichyl-phospho-mannose synthase
guanosine diphosphomannose-dolichol phosphate mannosyltransferase
mannosylphosphodolichol synthase
mannosylphosphoryldolichol synthase
Systematic name:
GDP-mannose:dolichyl-phosphate β-D-mannosyltransferase



Acts only on long-chain polyprenyl phosphates and α-dihydropolyprenyl phosphates that are larger than C35.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004582
CAS Registry Number: 62213-44-9
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Babczinski, P., Haselbeck, A. and Tanner, W.
    Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme.
    Eur. J. Biochem. 105: 509-515 (1980). [PMID: 6989607]
  2. Bretthauer, R.K., Wu, S. and Irwin, W.E.
    Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol phosphate in yeast (Hansenula holstii). A possible step in mannan synthesis.
    Biochim. Biophys. Acta 304: 736-747 (1973). [PMID: 4726855]
  3. Haselbeck, A.
    Purification of GDP mannose:dolichyl-phosphate O-β-D-mannosyltransferase from Saccharomyces cerevisiae.
    Eur. J. Biochem. 181: 663-668 (1989). [PMID: 2659345]
  4. Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W.
    Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives.
    Eur. J. Biochem. 105: 517-523 (1980). [PMID: 6445267]
  5. Richards, J.B. and Hemming, F.W.
    The transfer of mannose from guanosine diphosphate mannose to dolichol phosphate and protein by pig liver endoplasmic reticulum.
    Biochem. J. 130: 77-93 (1972). [PMID: 4655455]

[EC created 1976, modified 1983]