EC 2.4.1.62 - Ganglioside galactosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.62

Names

Accepted name:
ganglioside galactosyltransferase
Other names:
GM1-synthase
UDP galactose-LAC Tet-ceramide α-galactosyltransferase
UDP-galactose-GM2 galactosyltransferase
UDP-galactose-GM2 ganglioside galactosyltransferase
UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase
UDP-galactose—ceramide galactosyltransferase
uridine diphosphate D-galactose:glycolipid galactosyltransferase
uridine diphosphogalactose-GM2 galactosyltransferase
uridine diphosphogalactose-ceramide galactosyltransferase
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine β-1,3-D-galactosyltransferase
UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-(1→4)-β-D-glucosyl-N-acylsphingosine 3-β-D-galactosyltransferase
Systematic name:
UDP-α-D-galactose:N-acetyl-β-D-galactosaminyl-(1→4)-[α-N-acetylneuraminyl-(2→3)]-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide 3-β-D-galactosyltransferase

Reaction

Comments:

The substrate is also known as gangloside GM2, the product as gangloside GM1a.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047915
CAS Registry Number: 37217-28-0
UniProtKB/Swiss-Prot:

References

  1. Basu, S., Kaufman, B. and Roseman, S.
    Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose:glycolipid galactosyltransferase.
    J. Biol. Chem. 240: 4115-4117 (1965). [PMID: 5842076]
  2. Yip, G.B. and Dain, J.A.
    The enzymic synthesis of ganglioside. II. UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceramide galactosyltransferase in rat brain.
    Biochim. Biophys. Acta 206: 252-260 (1970). [PMID: 4987145]
  3. Yip, M.C.M. and Dain, J.A.
    Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosylceramide galactosyltransferase.
    Biochem. J. 118: 247-252 (1970). [PMID: 5484669]

[EC 2.4.1.62 created 1972, modified 2013]