EC 2.4.1.46 - Monogalactosyldiacylglycerol synthase

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IntEnz Enzyme Nomenclature
EC 2.4.1.46

Names

Accepted name:
monogalactosyldiacylglycerol synthase
Other names:
MGDG synthase
UDP galactose-1,2-diacylglycerol galactosyltransferase
UDP-galactose-diacylglyceride galactosyltransferase
UDP-galactose:diacylglycerol galactosyltransferase
UDPgalactose:1,2-diacylglycerol 3-β-D-galactosyltransferase
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase
1,2-diacylglycerol 3-β-galactosyltransferase
1β-MGDG
UDP-galactose:1,2-diacyl-sn-glycerol 3-β-D-galactosyltransferase
Systematic name:
UDP-α-D-galactose:1,2-diacyl-sn-glycerol 3-β-D-galactosyltransferase

Reaction

Comments:

This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046509
CAS Registry Number: 37277-55-7
UniProtKB/Swiss-Prot: (11) [show] [UniProt]

References

  1. Veerkamp, J.H.
    Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.
    Biochim. Biophys. Acta 348: 23-34 (1974). [PMID: 4838219]
  2. Wenger, D.A., Petipas, J.W. and Pieringer, R.A.
    The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.
    Biochemistry 7: 3700-3707 (1968). [PMID: 5681471]
  3. Miège, C., Maréchal, E., Shimojima, M., Awai, K., Block, M.A., Ohta, H., Takamiya, K., Douce, R. and Joyard, J.
    Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.
    Eur. J. Biochem. 265: 990-1001 (1999). [PMID: 10518794]
  4. Benning, C. and Ohta, H.
    Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.
    J. Biol. Chem. 280: 2397-2400 (2005). [PMID: 15590685]

[EC 2.4.1.46 created 1972, modified 2005]