EC 2.4.1.41 - Polypeptide N-acetylgalactosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.41

Names

Accepted name:
polypeptide N-acetylgalactosaminyltransferase
Other names:
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine:κ-casein polypeptide N-acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase
UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase
glycoprotein acetylgalactosaminyltransferase
polypeptide-N-acetylgalactosamine transferase
protein-UDP acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase
UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase
Systematic name:
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase

Reaction

Cofactors

Comments:

Requires both Mn2+ and Ca2+. The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, κ-casein, apofetuin and some other acceptors of high molecular mass.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004653
CAS Registry Number: 9075-15-4
UniProtKB/Swiss-Prot: (60) [show] [UniProt]

References

  1. Sugiura, M., Kawasaki, T. and Yamashina, I.
    Purification and characterization of UDP-GalNAc:polypeptide N-acetylgalactosamine transferase from an ascites hepatoma, AH 66.
    J. Biol. Chem. 257: 9501-9507 (1982). [PMID: 6809738]
  2. Takeuchi, M., Yoshikawa, M., Sasaki, R. and Chiba, H.
    Purification and characterization of UDP-N-acetylgalactosamine-κ-casein polypeptide N-acetylgalactosaminyltransferase from mammary-gland of lactating cow.
    Agric. Biol. Chem. 49: 1059-1069 (1985).

[EC 2.4.1.41 created 1972, modified 1989]