EC 2.4.1.40 - Glycoprotein-fucosylgalactoside α-N-acetylgalactosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.40

Names

Accepted name:
glycoprotein-fucosylgalactoside α-N-acetylgalactosaminyltransferase
Other names:
α-3-N-acetylgalactosaminyltransferase
A-transferase
UDP-N-acetyl-D-galactosamine:α-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase
UDP-GalNAc:Fucα1→2Galα1→3-N-acetylgalactosaminyltransferase
blood-group substance α-acetyltransferase
blood-group substance A-dependent acetylgalactosaminyltransferase
fucosylgalactose acetylgalactosaminyltransferase
histo-blood group A acetylgalactosaminyltransferase
histo-blood group A glycosyltransferase (Fucα1→2Galα1→3-N-acetylgalactosaminyltransferase)
histo-blood group A transferase
fucosylglycoprotein α-N-acetylgalactosaminyltransferase
fucosylgalactose α-N-acetylgalactosaminyltransferase
A transferase
UDP-N-acetyl-D-galactosamine:glycoprotein-α-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Systematic name:
UDP-N-acetyl-D-galactosamine:glycoprotein-α-L-fucosyl-(1→2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase

Reaction

Comments:

Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004380
CAS Registry Number: 9067-69-0
UniProtKB/Swiss-Prot:

References

  1. Kobata, A., Grollman, E.F. and Ginsburg, V.
    An enzymic basis for blood type A in humans.
    Arch. Biochem. Biophys. 124: 609-612 (1968). [PMID: 5661629]
  2. Takeya, A., Hosomi, O. and Ishiura, M.
    Complete purification and characterization of α-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene.
    J. Biochem. (Tokyo) 107: 360-368 (1990). [PMID: 2341371]
  3. Yates, A.D., Feeney, J., Donald, A.S.R. and Watkins, W.M.
    Characterization of a blood-group A-active tetrasaccharide synthesized by a blood-group-B gene-specified glycosyltransferase.
    Carbohydr. Res. 130: 251-260 (1984).

[EC 2.4.1.40 created 1972, modified 1999]