EC 2.4.1.38 - β-N-acetylglucosaminylglycopeptide β-1,4-galactosyltransferase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.4.1.38

Names

Accepted name:
β-N-acetylglucosaminylglycopeptide β-1,4-galactosyltransferase
Other names:
β-N-acetyl-β1-4-galactosyltransferase
UDPgalactose-glycoprotein galactosyltransferase
UDPgalactose:N-acetyl-β-D-glucosaminylglycopeptide β-1,4-galactosyltransferase
glycoprotein 4-β-galactosyl-transferase
glycoprotein β-galactosyltransferase
thyroid galactosyltransferase
thyroid glycoprotein β-galactosyltransferase
uridine diphosphogalactose-glycoprotein galactosyltransferase
UDP-galactose—glycoprotein galactosyltransferase
glycoprotein 4-β-galactosyltransferase
GalT
UDP-galactose:N-acetyl-β-D-glucosaminylglycopeptide β-1,4-galactosyltransferase
UDP-galactose:N-acetyl-β-D-glucosaminylglycopeptide 4-β-galactosyltransferase
Systematic name:
UDP-α-D-galactose:N-acetyl-β-D-glucosaminylglycopeptide 4-β-galactosyltransferase

Reaction

Comments:

Terminal N-acetyl-β-D-glucosaminyl residues in polysaccharides, glycoproteins and glycopeptides can act as acceptor. High activity is shown towards such residues in branched-chain polysaccharides when these are linked by β-1,6-links to galactose residues; lower activity towards residues linked to galactose by β-1,3-links. A component of EC 2.4.1.22 (lactose synthase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003831
CAS Registry Number: 37237-43-7
UniProtKB/Swiss-Prot: (13) [show] [UniProt]

References

  1. Beyer, T.A., Sadler, J.E., Rearick, J.I., Paulson, J.C. and Hill, R.L.
    Glucosyltransferases and their uses in assessing oligosaccharide structure and structure-function relationship.
    Adv. Enzymol. 52: 23-175 (1981).
  2. Blanken, W.M., Hooghwinkel, G.J.M. and van den Eijnden, D.H.
    Biosynthesis of blood-group I and i substances. Specificity of bovine colostrum β-N-acetyl-D-glucosaminide β1→4 galactosyltransferase.
    Eur. J. Biochem. 127: 547-552 (1982). [PMID: 6816588]
  3. Blanken, W.M. and van den Eijnden, D.H.
    Biosynthesis of terminal Galα1→3Galβ1→4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide α1→3-galactosyltransferase from calf thymus.
    J. Biol. Chem. 260: 12927-12934 (1985). [PMID: 3932335]
  4. Spiro, M.H. and Spiro, R.G.
    Glycoprotein biosynthesis: studies on thyroglobulin. Thyroid galactosyltransferase.
    J. Biol. Chem. 243: 6529-6537 (1968). [PMID: 5726898]

[EC 2.4.1.38 created 1972, modified 1976, modified 1980, modified 1986]