EC 2.4.1.198 - Phosphatidylinositol N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.198

Names

Accepted name:
phosphatidylinositol N-acetylglucosaminyltransferase
Other names:
UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase
uridine diphosphoacetylglucosamine α1,6-acetyl-D-glucosaminyltransferase
UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase
Systematic name:
UDP-N-acetyl-α-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase (configuration-retaining)

Reaction

Comments:

Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0017176
CAS Registry Number: 144388-35-2
UniProtKB/Swiss-Prot: (29) [show] [UniProt]

References

  1. Doering, T.L., Masteron, W.J., Englund, P.T. and Hart, G.W.
    Biosynthesis of the glycosyl phosphatidylinositol membrane anchor of the trypanosome variant surface glycoprotein. Origin of the non-acetylated glucosamine.
    J. Biol. Chem. 264: 11168-11173 (1989). [PMID: 2525555]
  2. Watanabe, R., Inoue, N., Westfall, B., Taron, C.H., Orlean, P., Takeda, J. and Kinoshita, T.
    The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.
    EMBO J. 17: 877-885 (1998). [PMID: 9463366]
  3. Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M. and Kinoshita, T.
    Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.
    EMBO J. 19: 4402-4411 (2000). [PMID: 10944123]

[EC 2.4.1.198 created 1992, modified 2002]