EC - Lipid-A-disaccharide synthase

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IntEnz Enzyme Nomenclature


Accepted name:
lipid-A-disaccharide synthase
Other name:
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-β-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase [incorrect]
Systematic name:
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosamine:2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-α-D-glucosaminyl 1-phosphate 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-D-glucosaminyltransferase



Involved with EC (acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase) and EC (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Escherichia coli.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008915
CAS Registry Number: 105843-81-0
UniProtKB/Swiss-Prot: (258) [show] [UniProt]


  1. Crowell, D.N., Reznikoff, W.S. and Raetz, C.R.H.
    Nucleotide sequence of the Escherichia coli gene for lipid A disaccharide synthase.
    J. Bacteriol. 169: 5727-5734 (1987). [PMID: 2824445]
  2. Ray, B.L., Painter, G. and Raetz, C.R.H.
    The biosynthesis of gram-negative endotoxin. Formation of lipid A disaccharides from monosaccharide precursors in extracts of Escherichia coli.
    J. Biol. Chem. 259: 4852-4859 (1984).

[EC created 1990]