EC 2.4.1.145 - α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.145

Names

Accepted name:
α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase
Other names:
N-acetylglucosaminyltransferase IV
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV
α-1,3-mannosylglycoprotein β-1,4-N-acetylglucosaminyltransferase
β-acetylglucosaminyltransferase IV
uridine diphosphoacetylglucosamine-glycopeptide β4-acetylglucosaminyltransferase IV
GnTIV
Systematic name:
UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-β-D-glucosaminyl)-α-D-mannosyl]-glycoprotein 4-β-N-acetyl-D-glucosaminyltransferase

Reaction

Comments:

R represents the remainder of the N-linked oligosaccharide in the glycoprotein acceptor. The best acceptor for this enzyme is probably the same as that favored by EC 2.4.1.144, β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008454
CAS Registry Number: 86498-16-0
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Gleeson, P.A. and Schachter, H.
    Control of glycoprotein synthesis.
    J. Biol. Chem. 258: 6162-6173 (1983). [PMID: 6222042]

[EC 2.4.1.145 created 1984, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984)]