EC 2.4.1.129 - Peptidoglycan glycosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.129

Names

Accepted name:
peptidoglycan glycosyltransferase
Other names:
PG-II
bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase
penicillin binding protein (3 or 1B)
peptidoglycan transglycosylase
undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1→4)-N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1→4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase
Systematic name:
[poly-N-acetyl-D-glucosaminyl-(1→4)-(N-acetyl-D-muramoylpentapeptide)]-diphosphoundecaprenol:[N-acetyl-D-glucosaminyl-(1→4)-N-acetyl-D-muramoylpentapeptide]-diphosphoundecaprenol disaccharidetransferase

Reaction

Comments:

The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol. Involved in the synthesis of cell-wall peptidoglycan.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008955
CAS Registry Number: 79079-04-2
UniProtKB/Swiss-Prot: (314) [show] [UniProt]

References

  1. Taku, A., Stuckey, M. and Fan, D.P.
    Purification of the peptidoglycan transglycosylase of Bacillus megaterium.
    J. Biol. Chem. 257: 5018-5022 (1982). [PMID: 6802846]
  2. Goffin, C. and Ghuysen, J.-M.
    Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs.
    Microbiol. Mol. Biol. Rev. 62: 1079-1093 (1998). [PMID: 9841666]
  3. van Heijenoort, J.
    Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
    Glycobiology 11: 25R-36R (2001). [PMID: 11320055]

[EC 2.4.1.129 created 1984, modified 2002]