EC 2.4.1.109 - Dolichyl-phosphate-mannose—protein mannosyltransferase

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IntEnz Enzyme Nomenclature
EC 2.4.1.109

Names

Accepted name:
dolichyl-phosphate-mannose—protein mannosyltransferase
Other names:
dolichol phosphomannose-protein mannosyltransferase
protein O-D-mannosyltransferase
dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase
dolichyl-phosphate-mannose-protein mannosyltransferase
dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase
Systematic name:
dolichyl-D-mannosyl-phosphate::L-threonyl/L-seryl-[protein] O-D-mannosyltransferase (configuration-inverting)

Reaction

Comments:

The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004169
CAS Registry Number: 74315-99-4
UniProtKB/Swiss-Prot: (28) [show] [UniProt]

References

  1. Babczinski, P., Haselbeck, A. and Tanner, W.
    Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme.
    Eur. J. Biochem. 105: 509-515 (1980). [PMID: 6989607]
  2. Palamarczyk, G., Lehle, L., Mankowski, T., Chojnacki, T. and Tanner, W.
    Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives.
    Eur. J. Biochem. 105: 517-523 (1980). [PMID: 6445267]

[EC 2.4.1.109 created 1983, modified 2014]