EC 2.3.3.8 - ATP citrate synthase

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IntEnz Enzyme Nomenclature
EC 2.3.3.8

Names

Accepted name:
ATP citrate synthase
Other names:
ATP citrate (pro-S)-lyase
ATP-citric lyase
ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO→acetyl-CoA] (ATP-dephosphorylating)
acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)
adenosine triphosphate citrate lyase
citrate cleavage enzyme
citrate-ATP lyase
citric cleavage enzyme
Systematic name:
acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]

Reaction

Comments:

The enzyme can be dissociated into components, two of which are identical with EC 4.1.3.34 (citryl-CoA lyase) and EC 6.2.1.18 (citrate—CoA ligase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00335
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003878
CAS Registry Number: 9027-95-6
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Lill, U., Schreil, A. and Eggerer, H.
    Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase.
    Eur. J. Biochem. 125: 645-650 (1982). [PMID: 6749502]
  2. Srere, P.A. and Lipmann, F.
    An enzymatic reaction between citrate, adenosine triphosphate and coenzyme A.
    J. Am. Chem. Soc. 75: 4874 (1953).

[EC 2.3.3.8 created 1965 as EC 4.1.3.8, modified 1986, transferred 2002 to EC 2.3.3.8]