EC 2.3.2.6 - Leucyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.2.6

Names

Accepted name:
leucyltransferase
Other names:
leucyl, phenylalanine-tRNA-protein transferase
leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase
leucyl-phenylalanine-transfer ribonucleate-protein transferase
leucyl/phenylalanyl-tRNA--protein transferase
leucyl-tRNA--protein transferase
L/F transferase
L-leucyl-tRNA:protein leucyltransferase
Systematic name:
L-leucyl-tRNALeu:protein leucyltransferase

Reactions

Cofactor

Comments:

Also transfers phenylalanyl groups. Requires a univalent cation. Peptides and proteins containing an N-terminal arginine, lysine or histidine residue can act as acceptors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008914
CAS Registry Number: 37257-22-0
UniProtKB/Swiss-Prot: (305) [show] [UniProt]

References

  1. Leibowitz, M.J. and Soffer, R.L.
    A soluble enzyme from Escherichia coli which catalyzes the transfer of leucine and phenylalanine from tRNA to acceptor proteins.
    Biochem. Biophys. Res. Commun. 36: 47-53 (1969). [PMID: 4894363]
  2. Leibowitz, M.J. and Soffer, R.L.
    Enzymatic modification of proteins. 3. Purification and properties of a leucyl, phenylalanyl transfer ribonucleic acid protein transferase from Escherichia coli.
    J. Biol. Chem. 245: 2066-2073 (1970). [PMID: 4909560]
  3. Soffer, R.L.
    Peptide acceptors in the leucine, phenylalanine transfer reaction.
    J. Biol. Chem. 248: 8424-8428 (1973). [PMID: 4587124]

[EC 2.3.2.6 created 1972, modified 1976, modified 2013]