EC 2.3.1.97 - Glycylpeptide N-tetradecanoyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.97

Names

Accepted name:
glycylpeptide N-tetradecanoyltransferase
Other names:
myristoyl-CoA-protein N-myristoyltransferase
myristoyl-coenzyme A:protein N-myristoyl transferase
myristoylating enzymes
peptide N-myristoyltransferase
protein N-myristoyltransferase
Systematic name:
tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase

Reaction

Comments:

The enzyme from yeast is highly specific for tetradecanoyl-CoA, and highly specific for N-terminal glycine in oligopeptides containing serine in the 5-position. The enzyme from mammalian heart transfers acyl groups to a specific 51 kDa acceptor protein.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00752
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004379
CAS Registry Number: 110071-61-9
UniProtKB/Swiss-Prot: (35) [show] [UniProt]

References

  1. Guertin, D., Gris-Miron, L. and Riendeau, D.
    Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue.
    Biochem. Cell Biol. 64: 1249-1255 (1986). [PMID: 3566958]
  2. Heuckeroth, R.O., Towler, D.A., Adams, S.P., Glaser, L. and Gordon, J.I.
    11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase.
    J. Biol. Chem. 263: 2127-2133 (1988). [PMID: 3123489]

[EC 2.3.1.97 created 1989, modified 1990]