EC - Fatty-acyl-CoA synthase

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IntEnz Enzyme Nomenclature


Accepted name:
fatty-acyl-CoA synthase
Other names:
yeast fatty acid synthase
FAS1 (gene name)
FAS2 (gene name)
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)



The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi-functional protein complex composed of two subunits. One subunit catalyses the reactions EC, 3-oxoacyl-[acyl-carrier-protein] reductase and EC, 3-oxoacyl-[acyl-carrier-protein] synthase, while the other subunit catalyses the reactions of EC, [acyl-carrier-protein] S-acetyltransferase, EC, [acyl-carrier-protein] S-malonyltransferase, EC, 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase, EC, enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) and EC, (R)-3-hydroxyacid ester dehydrogenase.The enzyme differs from the animal enzyme (EC in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004321
CAS Registry Number: 9045-77-6
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Schweitzer, E., Kniep, B., Castorph, H. and Holzner, U.
    Pantetheine-free mutants of the yeast fatty-acid-synthetase complex.
    Eur. J. Biochem. 39: 353-362 (1973). [PMID: 4590449]
  2. Wakil, S.J., Stoops, J.K. and Joshi, V.C.
    Fatty acid synthesis and its regulation.
    Annu. Rev. Biochem. 52: 537-579 (1983). [PMID: 6137188]
  3. Tehlivets, O., Scheuringer, K., Kohlwein, S. D.
    Fatty acid synthesis and elongation in yeast.
    Biochim. Biophys. Acta 1771: 255-270 (2007). [PMID: 16950653]

[EC created 1984, modified 2003, modified 2013]