EC 2.3.1.85 - Fatty-acid synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.85

Names

Accepted name:
fatty-acid synthase
Other name:
FASN (gene name)
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)

Reaction

Comments:

The animal enzyme is a multi-functional protein catalysing the reactions of EC 2.3.1.38 [acyl-carrier-protein] S-acetyltransferase, EC 2.3.1.39 [acyl-carrier-protein] S-malonyltransferase, EC 2.3.1.41 3-oxoacyl-[acyl-carrier-protein] synthase, EC 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase, EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, EC 1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) and EC 3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004312
CAS Registry Number: 9045-77-6
UniProtKB/Swiss-Prot:

References

  1. Stoops, J.K., Ross, P., Arslanian, M.J., Aune, K.C., Wakil, S.J. and Oliver, R.M.
    Physicochemical studies of the rat liver and adipose fatty acid synthetases.
    J. Biol. Chem. 254: 7418-7426 (1979). [PMID: 457689]
  2. Wakil, S.J., Stoops, J.K. and Joshi, V.C.
    Fatty acid synthesis and its regulation.
    Annu. Rev. Biochem. 52: 537-579 (1983). [PMID: 6137188]

[EC 2.3.1.85 created 1984]