EC 2.3.1.78 - Heparan-α-glucosaminide N-acetyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.78

Names

Accepted name:
heparan-α-glucosaminide N-acetyltransferase
Other name:
acetyl-CoA:α-glucosaminide N-acetyltransferase
Systematic name:
acetyl-CoA:heparan-α-D-glucosaminide N-acetyltransferase

Reaction

Comments:

Brings about the acetylation of glucosamine groups of heparan sulfate and heparin from which the sulfate has been removed. Also acts on heparin. Not identical with EC 2.3.1.3 glucosamine N-acetyltransferase or EC 2.3.1.4 glucosamine-phosphate N-acetyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015019
CAS Registry Number: 79955-83-2
UniProtKB/Swiss-Prot:

References

  1. Klein, V., Kresse, H. and von Figura, K.
    Sanfilippo syndrome type C: deficiency of acetyl-CoA:α-glucosaminide N-acetyltransferase in skin fibroblasts.
    Proc. Natl. Acad. Sci. USA 75: 5185-5189 (1978). [PMID: 33384]
  2. Pohlmann, R., Klein, U., Fromme, H.G. and von Figura, K.
    Localisation of acetyl-CoA: α-glucosaminide N-acetyltransferase in microsomes and lysosomes of rat liver.
    Hoppe-Seyler's Z. Physiol. Chem. 362: 1199-1207 (1981). [PMID: 7346380]

[EC 2.3.1.78 created 1984]