EC 2.3.1.61 - Dihydrolipoyllysine-residue succinyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.61

Names

Accepted name:
dihydrolipoyllysine-residue succinyltransferase
Other names:
dihydrolipoamide S-succinyltransferase
dihydrolipoamide succinyltransferase
dihydrolipoic transsuccinylase
dihydrolipolyl transsuccinylase
dihydrolipoyl transsuccinylase
lipoate succinyltransferase (Escherichia coli)
lipoic transsuccinylase
lipoyl transsuccinylase
succinyl-CoA:dihydrolipoamide S-succinyltransferase
succinyl-CoA:dihydrolipoate S-succinyltransferase
lipoate succinyltransferase
enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase
succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase
Systematic name:
succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase

Reaction

Comments:

A multimer (24-mer) of this enzyme forms the core of the multienzyme complex, and binds tightly both EC 1.2.4.2, oxoglutarate dehydrogenase (succinyl-transferring) and EC 1.8.1.4, dihydrolipoyl dehydrogenase. The lipoyl group of this enzyme is reductively succinylated by EC 1.2.4.2, and the only observed direction catalysed by EC 2.3.1.61 is that where this succinyl group is passed to coenzyme A.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004149
CAS Registry Number: 9032-28-4
UniProtKB/Swiss-Prot: (59) [show] [UniProt]

References

  1. Derosier, D.J., Oliver, R.M. and Reed, L.J.
    Crystallization and preliminary structural analysis of dihydrolipoyl transsuccinylase, the core of the 2-oxoglutarate dehydrogenase complex.
    Proc. Natl. Acad. Sci. USA 68: 1135-1137 (1971). [PMID: 4942179]
  2. Reed, L.J. and Cox, D.J.
    Multienzyme complexes.
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 1, Academic Press, New York, 1970, 213-240
  3. Knapp, J.E., Mitchell, D.T., Yazdi, M.A., Ernst, S.R., Reed, L.J. and Hackert, M.L.
    Crystal structure of the truncated cubic core component of the Escherichia coli 2-oxoglutarate dehydrogenase multienzyme complex.
    J. Mol. Biol. 280: 655-668 (1998). [PMID: 9677295]
  4. Perham, R.N.
    Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
    Annu. Rev. Biochem. 69: 961-1004 (2000). [PMID: 10966480]

[EC 2.3.1.61 created 1978, modified 2003]