EC - Phosphatidylcholine—sterol O-acyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphatidylcholine—sterol O-acyltransferase
Other names:
LCAT (lecithin-cholesterol acyltransferase)
lecithin:cholesterol acyltransferase
lecithin—cholesterol acyltransferase
lysolecithin acyltransferase
phospholipid—cholesterol acyltransferase
Systematic name:
phosphatidylcholine:sterol O-acyltransferase



Palmitoyl, oleoyl and linoleoyl residues can be transferred; a number of sterols, including cholesterol, can act as acceptors. The bacterial enzyme also catalyses the reactions of EC phospholipase A2 and EC lysophospholipase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00110
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004607
CAS Registry Number: 9031-14-5
UniProtKB/Swiss-Prot: (12) [show] [UniProt]


  1. Bartlett, K., Keat, M.J. and Mercer, E.I.
    Biosynthesis of sterol esters in Phycomyces blakesleeanus.
    Phytochemistry 13: 1107-1113 (1974).
  2. Buckley, J.T., Halasa, L.N. and Macintyre, S.
    Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase.
    J. Biol. Chem. 257: 3320-3325 (1982). [PMID: 7061477]
  3. Glomset, J.A.J.
    The plasma lecithins:cholesterol acyltransferase reaction.
    Lipid Res. 9: 155-167 (1968). [PMID: 4868699]
  4. Vahouny, G.V. and Tradwell, C.R.
    Enzymatic synthesis and hydrolysis of cholesterol esters.
    Methods Biochem. Anal. 16: 219-272 (1968). [PMID: 4877146]

[EC created 1972, modified 1976]