EC 2.3.1.26 - Sterol O-acyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.26

Names

Accepted name:
sterol O-acyltransferase
Other names:
ACAT
acyl coenzyme A-cholesterol-O-acyltransferase
acyl-CoA:cholesterol acyltransferase
acylcoenzyme A:cholesterol O-acyltransferase
cholesterol acyltransferase
cholesterol ester synthase
cholesterol ester synthetase
cholesteryl ester synthetase
sterol-ester synthase
sterol-ester synthetase
Systematic name:
acyl-CoA:cholesterol O-acyltransferase

Reaction

Comments:

The animal enzyme is highly specific for transfer of acyl groups with a single cis double bond that is nine carbon atoms distant from the carboxy group.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034736
CAS Registry Number: 9027-63-8
UniProtKB/Swiss-Prot: (17) [show] [UniProt]

References

  1. Sgoutas, D.S.
    Effect of geometry and position of ethylenic bond upon acyl coenzymeA--cholesterol-O-acyltransferase.
    Biochemistry 9: 1826-1833 (1970). [PMID: 5439042]
  2. Spector, A.A., Mathur, S.N. and Kaduce, T.L.
    Role of acylcoenzyme A: cholesterol O-acyltransferase in cholesterol metabolism.
    Prog. Lipid Res. 18: 31-53 (1979). [PMID: 42927]
  3. Taketani, S., Nishino, T., Katsuki, H.
    Characterization of sterol-ester synthetase in Saccharomyces cerevisiae.
    Biochim. Biophys. Acta 575: 148-155 (1979). [PMID: 389289]

[EC 2.3.1.26 created 1972]