EC 2.3.1.21 - Carnitine O-palmitoyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.21

Names

Accepted name:
carnitine O-palmitoyltransferase
Other names:
L-carnitine palmitoyltransferase
CPT
CPT I (outer membrane carnitine palmitoyl transferase)
CPT-A
CPT-B
CPTi
CPTo
acylcarnitine transferase
carnitine palmitoyltransferase
carnitine palmitoyltransferase I
carnitine palmitoyltransferase II
carnitine palmitoyltransferase-A
outer malonyl-CoA inhibitable carnitine palmitoyltransferase
palmitoylcarnitine transferase
Systematic name:
palmitoyl-CoA:L-carnitine O-palmitoyltransferase

Reaction

Comments:

Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00402
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004095
CAS Registry Number: 9068-41-1
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Derrick, J.P., Tubbs, P.K. and Ramsay, R.R.
    Purification and properties of an easily solubilized L-carnitine palmitoyltransferase from beef-liver mitochondria.
    Biochem. Soc. Trans. 14: 698 (1986).
  2. Healy, M.J., Kerner, J. and Bieber, L.L.
    Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?
    Biochem. J. 249: 231-237 (1988). [PMID: 3342008]
  3. Miyazawa, S., Ozasa, H., Osumi, T. and Hashimoto, T.
    Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver.
    J. Biochem. (Tokyo) 94: 529-542 (1983). [PMID: 6630173]

[EC 2.3.1.21 created 1972]