EC 2.3.1.161 - Lovastatin nonaketide synthase

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IntEnz Enzyme Nomenclature
EC 2.3.1.161

Names

Accepted name:
lovastatin nonaketide synthase
Other names:
LNKS
LovB
LovC
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing)
Systematic name:
acyl-CoA:malonyl-CoA C-acyltransferase (dihydromonacolin L acid-forming)

Reaction

Comments:

This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. The PKS catalyses many of the chain building reactions of EC 2.3.1.85, fatty-acid synthase, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00529
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050637
CAS Registry Number: 235426-97-8
UniProtKB/Swiss-Prot:

References

  1. Auclair, K., Sutherland, A., Kennedy, J., Witter, D.J., van der Heever, J.P., Hutchinson, C.R. and Vederas, J.C.
    Lovastatin nonaketide synthase catalyses an intramolecular Diels-Alder reaction of a substrate analogue.
    J. Am. Chem. Soc. 122: 11519-11520 (2000).
  2. Kennedy, J., Auclair, K., Kendrew, S. G., Park, C., Vederas, J. C., Hutchinson, C. R.
    Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis.
    Science 284: 1368-1372 (1999). [PMID: 10334994]
  3. Ma, S. M., Li, J. W., Choi, J. W., Zhou, H., Lee, K. K., Moorthie, V. A., Xie, X., Kealey, J. T., Da Silva, N. A., Vederas, J. C., Tang, Y.
    Complete reconstitution of a highly reducing iterative polyketide synthase.
    Science 326: 589-592 (2009). [PMID: 19900898]

[EC 2.3.1.161 created 2002, modified 2015, modified 2016]