EC - Acridone synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
acridone synthase
Systematic name:
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)



Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00403
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050635
CAS Registry Number: 99085-53-7


  1. Baumert, A., Maier, W., Gröger, D. and Deutzmann, R.
    Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L.
    Z. Naturforsch. C: Biosci. 49: 26-32 (1994). [PMID: 8148006]
  2. Maier, W., Baumert, A., Schumann, B., Furukawa, H. and Gröger, D.
    Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures.
    Phytochemistry 32: 691-698 (1993).
  3. Lukacin, R., Springob, K., Urbanke, C., Ernwein, C., Schröder, G., Schröder, J. and Matern, U.
    Native acridone synthases I and II from Ruta graveolens L. form homodimers.
    FEBS Lett. 448: 135-140 (1999). [PMID: 10217426]
  4. Junghanns, K.T., Kneusel, R.E., Gröger, D. and Matern, U.
    Differential regulation and distribution of acridone synthase in Ruta graveolens.
    Phytochemistry 49: 403-411 (1998). [PMID: 9747538]

[EC created 2002]