EC 2.3.1.129 - Acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase

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IntEnz Enzyme Nomenclature
EC 2.3.1.129

Names

Accepted name:
acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase
Other names:
UDP-N-acetylglucosamine acyltransferase
uridine diphosphoacetylglucosamine acyltransferase
acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetyl-α-D-glucosamine 3-O-(3-hydroxytetradecanoyl)transferase
Systematic name:
(R)-3-hydroxymyristoyl-[acyl-carrier-protein]:UDP-N-acetyl-α-D-glucosamine 3-O-(3-hydroxymyristoyl)transferase

Reaction

Comments:

Involved with EC 2.4.1.182 (lipid-A-disaccharide synthase) and EC 2.7.1.130 (tetraacyldisaccharide 4'-kinase) in the biosynthesis of the phosphorylated glycolipid, Lipid A, in the outer membrane of Escherichia coli.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00094
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008780
CAS Registry Number: 105843-69-4
UniProtKB/Swiss-Prot: (268) [show] [UniProt]

References

  1. Anderson, M.S., Bulawa, C.E. and Raetz, C.R.H.
    The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli.
    J. Biol. Chem. 260: 15536-15541 (1985). [PMID: 3905795]

[EC 2.3.1.129 created 1990]