EC - 1-deoxy-D-xylulose-5-phosphate synthase

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IntEnz Enzyme Nomenclature


Accepted name:
1-deoxy-D-xylulose-5-phosphate synthase
Other names:
1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
1-deoxyxylulose-5-phosphate synthase
Systematic name:
pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)




Requires thiamine diphosphate. The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00635
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008661
UniProtKB/Swiss-Prot: (522) [show] [UniProt]


  1. Sprenger, G.A., Schörken, U., Weigert, T., Grolle, S., deGraaf, A.A., Taylor, S.V., Begley,
    Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.
    Proc. Natl. Acad. Sci. USA 94: 12857-12862 (1997). [PMID: 9371765]
  2. Kuzuyama, T., Takagi, M., Takahashi, S. and Seto, H.
    Cloning and characterization of 1-deoxy-D-xylulose 5-phosphate synthase from Streptomyces sp. strain CL190, which uses both the mevalonate and nonmevalonate pathways for isopentenyl diphosphate biosynthesis.
    J. Bacteriol. 182: 891-897 (2000). [PMID: 10648511]

[EC created 2001 as EC, transferred 2002 to EC]