EC 2.2.1.1 - Transketolase

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IntEnz Enzyme Nomenclature
EC 2.2.1.1

Names

Accepted name:
transketolase
Other names:
glycolaldehydetransferase
glycoaldehyde transferase
Systematic name:
sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase

Reactions

Cofactor

Comments:

A thiamine-diphosphate protein. Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO2 and R-CHOH-CO-CH2OH. The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00635
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004802
CAS Registry Number: 9014-48-6
UniProtKB/Swiss-Prot: (83) [show] [UniProt]

References

  1. de la Haba, G., Leder, I.G. and Racker, E.
    Crystalline transketolase from bakers' yeast: isolation and properties.
    J. Biol. Chem. 214: 409-426 (1955).
  2. Domagk, G.F. and Horecker, B.L.
    Fructose and erythrose metabolism in Alcaligenes faecalis.
    Arch. Biochem. Biophys. 109: 342-349 (1965).
  3. Horecker, B.L., Smyrniotis, P.Z. and Hurwitz, J.
    The role of xylulose 5-phosphate in the transketolase reaction.
    J. Biol. Chem. 223: 1009-1019 (1956).
  4. Racker, E.
    Transketolase.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 5, 1961, 397-412

[EC 2.2.1.1 created 1961]