EC - Glycine amidinotransferase

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IntEnz Enzyme Nomenclature


Accepted name:
glycine amidinotransferase
Other names:
arginine-glycine amidinotransferase
arginine-glycine transamidinase
glycine transamidinase
Systematic name:
L-arginine:glycine amidinotransferase



Canavanine can act instead of arginine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0015068
CAS Registry Number: 9027-35-4
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Borsook, H. and Dubnoff, J.W.
    The formation of glycocyamine in animal tissues.
    J. Biol. Chem. 138: 389-403 (1941).
  2. Conconi, F. and Grazi, E.
    Transamidinase of hog kidney. I. Purification and properties.
    J. Biol. Chem. 240: 2461-2464 (1965). [PMID: 14304853]
  3. McGuire, D.M., Tormanen, C.D., Segal, I.S. and van Pilsum, J.F.
    The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats, purification and some properties of rat kidney transamidinase.
    J. Biol. Chem. 255: 1152-1159 (1980). [PMID: 6766137]
  4. Ratner, S.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 6, Academic Press, New York, 1962, 267-275
  5. Ratner, S. and Rochovansky, O.
    Biosynthesis of guanidinoacetic acid. I. Purification and properties of transamidinase.
    Arch. Biochem. Biophys. 63: 277-295 (1956). [PMID: 13355454]
  6. Ratner, S. and Rochovansky, O.
    Biosynthesis of guanidinoacetic acid. II. Mechanism of amidine group transfer.
    Arch. Biochem. Biophys. 63: 296-315 (1956). [PMID: 13355455]
  7. Walker, J.B.
    Biosynthesis of arginine from canavanine and ornithine in kidney.
    J. Biol. Chem. 218: 549-556 (1956). [PMID: 13278360]
  8. Walker, J.B.
    Studies on the mechanism of action of kidney transamidinase.
    J. Biol. Chem. 224: 57-66 (1957). [PMID: 13398387]

[EC created 1961 as EC, transferred 1965 to EC]