EC - Thiopurine S-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
thiopurine S-methyltransferase
Other names:
6-thiopurine transmethylase
mercaptopurine methyltransferase
thiopurine methyltransferase
Systematic name:
S-adenosyl-L-methionine:thiopurine S-methyltransferase



Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC thiol S-methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008119
UniProtKB/Swiss-Prot: (94) [show] [UniProt]


  1. Remy, C.N.
    Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues.
    J. Biol. Chem. 238: 1078-1084 (1963). [PMID: 13981612]
  2. Woodson, L.C., Ames, M.M., Selassie, C.D, Hansch, C. and Weinshilbaum, R.M.
    Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.
    Mol. Pharmacol. 24: 471-478 (1983). [PMID: 6633508]
  3. Woodson, L.C. and Weinshilbaum, R.M.
    Human kidney thiopurine methyltransferase. Purification and biochemical properties.
    Biochem. Pharmacol. 32: 819-826 (1983). [PMID: 6838629]

[EC created 1984]