EC - Methylated-DNA—[protein]-cysteine S-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
methylated-DNA—[protein]-cysteine S-methyltransferase
Other names:
6-O-methylguanine-DNA methyltransferase
Systematic name:
DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase



This protein is involved in the repair of alkylated DNA. It acts only on the alkylated DNA (cf. EC DNA-3-methyladenine glycosidase I and EC DNA-3-methyladenine glycosidase II). This enzyme catalyses only one turnover and therefore is not strictly catalytic.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00320
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003908
CAS Registry Number: 77271-19-3
UniProtKB/Swiss-Prot: (56) [show] [UniProt]


  1. Foote, R.S., Mitra, S. and Pal, B.C.
    Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli.
    Biochem. Biophys. Res. Commun. 97: 654-659 (1980). [PMID: 7008792]
  2. Olsson, M. and Lindehl, T.
    Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue.
    J. Biol. Chem. 255: 10569-10571 (1980). [PMID: 7000780]
  3. Pegg, A.E. and Byers, T.L.
    Repair of DNA containing O6-alkylguanine.
    FASEB J. 6: 2302-2310 (1992). [PMID: 1544541]

[EC created 1982, modified 1983, modified 1999, modified 2003]