EC 2.1.1.6 - Catechol O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.6

Names

Accepted name:
catechol O-methyltransferase
Other names:
COMT I
COMT II
MB-COMT (membrane-bound form of catechol-O-methyltransferase)
S-COMT (soluble form of catechol-O-methyltransferase)
catechol methyltransferase
catecholamine O-methyltransferase
Systematic name:
S-adenosyl-L-methionine:catechol O-methyltransferase

Reaction

Comments:

The mammalian enzyme acts more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102084 , GO:0016206 , GO:0102938
CAS Registry Number: 9012-25-3
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Axelrod, J. and Tomchick, R.
    Enzymatic O-methylation of epinephrine and other catechols.
    J. Biol. Chem. 233: 702-705 (1958). [PMID: 13575440]
  2. Gulliver, P.A. and Tipton, K.F.
    The purification and properties of pig brain catechol-O-methyltransferase.
    J. Neurochem. 32: 1525-1529 (1979). [PMID: 438821]
  3. Huh, M.M.O. and Friedhof, A.J.
    Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization.
    J. Biol. Chem. 254: 299-308 (1979). [PMID: 762061]

[EC 2.1.1.6 created 1965]