EC 2.1.1.44 - L-histidine Nα-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.44

Names

Accepted name:
L-histidine Nα-methyltransferase
Other names:
dimethylhistidine methyltransferase
histidine-α-N-methyltransferase
S-adenosyl-L-methionine:α-N,α-N-dimethyl-L-histidine α-N-methyltransferase
dimethylhistidine N-methyltransferase
S-adenosyl-L-methionine:Nα,Nα-dimethyl-L-histidine Nα-methyltransferase
Systematic name:
S-adenosyl-L-methionine:L-histidine Nα-methyltransferase (hercynine-forming)

Reactions

Comments:

Part of the biosynthetic pathway of ergothioneine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030745
CAS Registry Number: 62213-53-0
UniProtKB/Swiss-Prot:

References

  1. Ishikawa, Y. and Melville, D.B.
    The enzymatic α-N-methylation of histidine.
    J. Biol. Chem. 245: 5967-5973 (1970). [PMID: 5484456]
  2. Seebeck, F. P.
    In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.
    J. Am. Chem. Soc. 132: 6632-6633 (2010). [PMID: 20420449]

[EC 2.1.1.44 created 1976, modified 2013]