EC - Protein N-terminal methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
protein N-terminal methyltransferase
Other names:
NMT1 (gene name)
METTL11A (gene name)
Systematic name:
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] methyltransferase



This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. When the terminal amino acid is L-proline, the enzyme catalyses two successive methylations of its α-amino group. When the first amino acid is either L-alanine or L-serine, the enzyme catalyses three successive methylations. The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids [1,2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (18) [show] [UniProt]


  1. Webb, K. J., Lipson, R. S., Al-Hadid, Q., Whitelegge, J. P., Clarke, S. G.
    Identification of protein N-terminal methyltransferases in yeast and humans.
    Biochemistry 49: 5225-5235 (2010). [PMID: 20481588]
  2. Tooley, C. E., Petkowski, J. J., Muratore-Schroeder, T. L., Balsbaugh, J. L., Shabanowitz, J., Sabat, M., Minor, W., Hunt, D. F., Macara, I. G.
    NRMT is an α-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
    Nature 466: 1125-1128 (2010). [PMID: 20668449]

[EC created 2012]