EC 2.1.1.233 - [phosphatase 2A protein]-leucine-carboxy methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.233

Names

Accepted name:
[phosphatase 2A protein]-leucine-carboxy methyltransferase
Other names:
leucine carboxy methyltransferase-1
LCMT1
Systematic name:
S-adenosyl-L-methionine:[phosphatase 2A protein]-leucine O-methyltransferase

Reaction

Comments:

Methylates the C-terminal leucine of phosphatase 2A. A key regulator of protein phosphatase 2A. The methyl ester is hydrolysed by EC 3.1.1.89 (protein phosphatase methylesterase-1). Occurs mainly in the cytoplasm, Golgi region and late endosomes.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (21) [show] [UniProt]

References

  1. De Baere, I., Derua, R., Janssens, V., Van Hoof, C., Waelkens, E., Merlevede, W., Goris, J.
    Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.
    Biochemistry 38: 16539-16547 (1999). [PMID: 10600115]
  2. Tsai, M. L., Cronin, N., Djordjevic, S.
    The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.
    Acta Crystallogr. D Biol. Crystallogr. 67: 14-24 (2011). [PMID: 21206058]

[EC 2.1.1.233 created 2011]