EC - TRNA (adenine58-N1)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
tRNA (adenine58-N1)-methyltransferase
Other names:
tRNA m1A58 methyltransferase
tRNA (m1A58) methyltransferase
tRNA (m1A58) Mtase
Systematic name:
S-adenosyl-L-methionine:tRNA (adenine58-N1)-methyltransferase



The enzyme specifically methylates adenine58 in tRNA. The methylation of A58 is critical for maintaining the stability of initiator tRNAMet in yeast [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (22) [show] [UniProt]


  1. Droogmans, L., Roovers, M., Bujnicki, J. M., Tricot, C., Hartsch, T., Stalon, V., Grosjean, H.
    Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures.
    Nucleic Acids Res. 31: 2148-2156 (2003). [PMID: 12682365]
  2. Varshney, U., Ramesh, V., Madabushi, A., Gaur, R., Subramanya, H. S., RajBhandary, U. L.
    Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase.
    Nucleic Acids Res. 32: 1018-1027 (2004). [PMID: 14960715]
  3. Anderson, J., Phan, L., Hinnebusch, A. G.
    The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae.
    Proc. Natl. Acad. Sci. USA 97: 5173-5178 (2000). [PMID: 10779558]

[EC created 1972 as EC, part-transferred 2011 to EC]