EC - TRNA (cytosine38-C5)-methyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
tRNA (cytosine38-C5)-methyltransferase
Other names:
hDNMT2 (gene name)
DNMT2 (gene name)
TRDMT1 (gene name)
Systematic name:
S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase



The eukaryotic enzyme catalyses methylation of cytosine38 in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC). Methylation by Dnmt2 protects tRNAs against stress-induced cleavage by ribonuclease [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00089
Structural data: CSA , EC2PDB


  1. Goll, M. G., Kirpekar, F., Maggert, K. A., Yoder, J. A., Hsieh, C. L., Zhang, X., Golic, K. G., Jacobsen, S. E., Bestor, T. H.
    Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.
    Science 311: 395-398 (2006). [PMID: 16424344]
  2. Jurkowski, T. P., Meusburger, M., Phalke, S., Helm, M., Nellen, W., Reuter, G., Jeltsch, A.
    Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism.
    RNA 14: 1663-1670 (2008). [PMID: 18567810]
  3. Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., Lyko, F.
    RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage.
    Genes Dev. 24: 1590-1595 (2010). [PMID: 20679393]

[EC created 2011]