EC 2.1.1.203 - TRNA (cytosine34-C5)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.203

Names

Accepted name:
tRNA (cytosine34-C5)-methyltransferase
Other names:
hTrm4 Mtase
hTrm4 methyltransferase
hTrm4 (gene name)
tRNA:m5C-methyltransferase [ambiguous]
Systematic name:
S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase

Reaction

Comments:

The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors. The intron in the human pre-tRNALeu(CAA) is indispensable for the C5-methylation of cytosine in the first position of the anticodon. It is not able to form 5-methylcytosine at positions 48 and 49 of human and yeast tRNA precursors [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Brzezicha, B., Schmidt, M., Makalowska, I., Jarmolowski, A., Pienkowska, J., Szweykowska-Kulinska, Z.
    Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNALeu(CAA).
    Nucleic Acids Res. 34: 6034-6043 (2006). [PMID: 17071714]

[EC 2.1.1.203 created 2011]