EC - 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase
Other names:
18S rRNA dimethylase Dim1p
m62A dimethylase
Systematic name:
S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase



DIM1 is involved in pre-rRNA processing [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052909
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Lafontaine, D., Vandenhaute, J., Tollervey, D.
    The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.
    Genes Dev. 9: 2470-2481 (1995). [PMID: 7590228]
  2. Lafontaine, D. L., Preiss, T., Tollervey, D.
    Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?
    Mol. Cell. Biol. 18: 2360-2370 (1998). [PMID: 9528805]
  3. Pulicherla, N., Pogorzala, L. A., Xu, Z., O Farrell, H. C., Musayev, F. N., Scarsdale, J. N., Sia, E. A., Culver, G. M., Rife, J. P.
    Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases.
    J. Mol. Biol. 391: 884-893 (2009). [PMID: 19520088]
  4. Lafontaine, D., Delcour, J., Glasser, A. L., Desgres, J., Vandenhaute, J.
    The DIM1 gene responsible for the conserved m62Am62A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast.
    J. Mol. Biol. 241: 492-497 (1994). [PMID: 8064863]
  5. Brown, J., Trafimow, D.
    Generalization of the negativity effect to self-attributions.
    Psychol Rep 93: 638-640 (2003). [PMID: 14650698]

[EC created 1976 as EC, part-transferred 2010 to EC]