EC 2.1.1.172 - 16S rRNA (guanine1207-N2)-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.172

Names

Accepted name:
16S rRNA (guanine1207-N2)-methyltransferase
Other name:
m2G1207 methyltransferase
Systematic name:
S-adenosyl-L-methionine:16S rRNA (guanine1207-N2)-methyltransferase

Reaction

Comments:

The enzyme reacts well with 30S subunits reconstituted from 16S RNA transcripts and 30S proteins but is almost inactive with the corresponding free RNA [1]. The enzyme specifically methylates guanine1207 at N2 in 16S rRNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052914
UniProtKB/Swiss-Prot: (140) [show] [UniProt]

References

  1. Tscherne, J. S., Nurse, K., Popienick, P., Ofengand, J.
    Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli.
    J. Biol. Chem. 274: 924-929 (1999). [PMID: 9873033]
  2. Sunita, S., Purta, E., Durawa, M., Tkaczuk, K. L., Swaathi, J., Bujnicki, J. M., Sivaraman, J.
    Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC.
    Nucleic Acids Res. 35: 4264-4274 (2007). [PMID: 17576679]

[EC 2.1.1.172 created 1976 as EC 2.1.1.52, part-transferred 2010 to EC 2.1.1.172]