EC 2.1.1.101 - Macrocin O-methyltransferase

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IntEnz Enzyme Nomenclature
EC 2.1.1.101

Names

Accepted name:
macrocin O-methyltransferase
Other names:
S-adenosyl-L-methionine-macrocin O-methyltransferase
macrocin methyltransferase
MOMT
Systematic name:
S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase

Reaction

Cofactor

Comments:

Requires Mg2+, Mn2+ or Co2+. The 3-hydroxy group of a 2-O-methyl-6-deoxy-D-allose residue in the macrolide antibiotic macrosin acts as methyl acceptor. Isolated from Streptomyces fradiae. Tylosin is a macrolide antibiotic. Not identical with EC 2.1.1.102, demethylmacrocin O-methyltransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0030769
CAS Registry Number: 79468-52-3
UniProtKB/Swiss-Prot:

References

  1. Bauer, N.J., Kreuzman, A.J., Dotzlaf, J.E. and Yeh, W.-K.
    Purification, characterization, and kinetic mechanism of S-adenosyl-L-methionine:macrocin O-methyltransferase from Streptomyces fradiae.
    J. Biol. Chem. 263: 15619-15625 (1988). [PMID: 3170601]
  2. Kreuzman, A.J., Turner, J.R. and Yeh, W.-K.
    Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis. Substrate specificity, enzyme inhibition, and kinetic mechanism.
    J. Biol. Chem. 263: 15626-15633 (1988). [PMID: 3170602]

[EC 2.1.1.101 created 1992]