EC 1.9.3.1 - Cytochrome-c oxidase

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IntEnz Enzyme Nomenclature
EC 1.9.3.1

Names

Accepted name:
cytochrome-c oxidase
Other names:
NADH cytochrome c oxidase
Warburg's respiratory enzyme
complex IV (mitochondrial electron transport)
cytochrome a3
cytochrome aa3
cytochrome oxidase
ferrocytochrome c oxidase
indophenol oxidase
indophenolase
Systematic name:
ferrocytochrome-c:oxygen oxidoreductase

Reaction

Cofactor

Comments:

A cytochrome of the a type containing copper. The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. Several bacteria appear to contain analogous oxidases.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00074 , PROSITE:PDOC00075 , PROSITE:PDOC00663
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004129
CAS Registry Number: 9001-16-5
UniProtKB/Swiss-Prot: (554) [show] [UniProt]

References

  1. Keilin, D. and Hartree, E.F.
    Cytochrome oxidase.
    Proc. R. Soc. Lond. B Biol. Sci. 125: 171-186 (1938).
  2. Keilin, D. and Hartree, E.F.
    Cytochrome and cytochrome oxidase.
    Proc. R. Soc. Lond. B Biol. Sci. 127: 167-191 (1939).
  3. Wainio, W.W., Eichel, B. and Gould, A.
    Ion and pH optimum for the oxidation of ferrocytochrome c by cytochrome c oxidase in air.
    J. Biol. Chem. 235: 1521-1525 (1960).
  4. Yonetani, T.
    Studies on cytochrome oxidase. II. Steady state properties.
    J. Biol. Chem. 235: 3138-3243 (1960). [PMID: 13787372]
  5. Yonetani, T.
    Studies on cytochrome oxidase. III. Improved preparation and some properties.
    J. Biol. Chem. 236: 1680-1688 (1961). [PMID: 13787373]

[EC 1.9.3.1 created 1961, modified 2000]