EC 1.8.4.8 - Phosphoadenylyl-sulfate reductase (thioredoxin)

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IntEnz Enzyme Nomenclature
EC 1.8.4.8

Names

Accepted name:
phosphoadenylyl-sulfate reductase (thioredoxin)
Other names:
3'-phosphoadenylylsulfate reductase
PAPS reductase
PAPS reductase, thioredoxin-dependent
adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)
phosphoadenosine-phosphosulfate reductase
thioredoxin:3'-phospho-adenylylsulfate reductase
thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase
Systematic name:
adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)

Reaction

Comments:

Specific for PAPS. The enzyme from Escherichia coli will use thioredoxins from other species.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004604
CAS Registry Number: 9068-63-7
UniProtKB/Swiss-Prot: (153) [show] [UniProt]

References

  1. Berendt, U., Haverkamp, T., Prior, A., Schwenn, J.D.
    Reaction mechanism of thioredoxin:3'-phospho-adenylylsulfate reductase investigated by site-directed mutagenesis.
    Eur. J. Biochem. 233: 347-356 (1995). [PMID: 7588765]

[EC 1.8.4.8 created 1999 as EC 1.8.99.4, transferred 2000 to EC 1.8.4.8]