EC 1.5.1.34 - 6,7-dihydropteridine reductase

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IntEnz Enzyme Nomenclature
EC 1.5.1.34

Names

Accepted name:
6,7-dihydropteridine reductase
Other names:
6,7-dihydropteridine:NAD(P)H oxidoreductase
DHPR
NAD(P)H2:6,7-dihydropteridine oxidoreductase
NADH-dihydropteridine reductase
NADPH-dihydropteridine reductase
NADPH-specific dihydropteridine reductase
dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase
dihydropteridine reductase
dihydropteridine reductase (NADH)
5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase
Systematic name:
5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase

Reactions

Comments:

The substrate is the quinonoid form of dihydropteridine. Not identical with EC 1.5.1.3 dihydrofolate reductase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00060
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004155
CAS Registry Number: 9074-11-7
UniProtKB/Swiss-Prot:

References

  1. Harano, T.
    New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin.
    Insect Biochem. 2: 385-399 (1972).
  2. Hasegawa, H.
    Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH.
    J. Biochem. (Tokyo) 81: 169-177 (1977). [PMID: 191436]
  3. Kaufman, S.
    Phenylalanine hydroxylase.
    Methods Enzymol. 5: 809-816 (1962).
  4. Lind, K.E.
    Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines.
    Eur. J. Biochem. 25: 560-562 (1972). [PMID: 4402916]
  5. Nakanishi, N., Hasegawa, H. and Watabe, S.
    A new enzyme, NADPH-dihydropteridine reductase in bovine liver.
    J. Biochem. (Tokyo) 81: 681-685 (1977). [PMID: 16875]

[EC 1.5.1.34 created 1972 as EC 1.6.99.7, modified 1981 (EC 1.6.99.10 created 1978, incorporated 1981), transferred 2003 to EC 1.5.1.34]