EC 1.4.3.5 - Pyridoxal 5'-phosphate synthase

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IntEnz Enzyme Nomenclature
EC 1.4.3.5

Names

Accepted name:
pyridoxal 5'-phosphate synthase
Other names:
PMP oxidase
pyridoxamine 5'-phosphate oxidase
pyridoxamine phosphate oxidase
pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)
pyridoxine (pyridoxamine) 5'-phosphate oxidase
pyridoxine (pyridoxamine)phosphate oxidase
pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) [incorrect]
pyridoxamine-phosphate oxidase
PdxH
Systematic name:
pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)

Reactions

Cofactor

Comments:

A flavoprotein (FMN). In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00815
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004733
CAS Registry Number: 9029-21-4
UniProtKB/Swiss-Prot: (358) [show] [UniProt]

References

  1. Choi, J.-D., Bowers-Komro, D.M., Davis, M.D., Edmondson, D.E. and McCormick, D.B.
    Kinetic properties of pyridoxamine (pyridoxine)-5'-phosphate oxidase from rabbit liver.
    J. Biol. Chem. 258: 840-845 (1983). [PMID: 6822512]
  2. Wada, H. and Snell, E.E.
    The enzymatic oxidation of pyridoxine and pyridoxamine phosphates.
    J. Biol. Chem. 236: 2089-2095 (1961). [PMID: 13782387]
  3. Notheis, C., Drewke, C. and Leistner, E.
    Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli.
    Biochim. Biophys. Acta 1247: 265-271 (1995). [PMID: 7696318]
  4. Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S.
    Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
    FEBS Lett. 449: 45-48 (1999). [PMID: 10225425]
  5. Musayev, F.N., Di Salvo, M.L., Ko, T.-P., Schirch, V. and Safo, M.K.
    Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase.
    Protein Sci. 12: 1455-1463 (2003). [PMID: 12824491]
  6. Safo, M.K., Musayev, F.N. and Schirch, V.
    Structure of Escherichia coli pyridoxine 5'-phosphate oxidase in a tetragonal crystal form: insights into the mechanistic pathway of the enzyme.
    Acta Crystallogr. D Biol. Crystallogr. 61: 599-604 (2005). [PMID: 15858270]

[EC 1.4.3.5 created 1961, modified 2006]