EC 1.3.7.1 - 6-hydroxynicotinate reductase

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IntEnz Enzyme Nomenclature
EC 1.3.7.1

Names

Accepted name:
6-hydroxynicotinate reductase
Other names:
6-hydroxynicotinic reductase
6-oxotetrahydronicotinate dehydrogenase
HNA reductase
6-oxotetrahydro-nicotinate dehydrogenase
1,4,5,6-tetrahydro-6-oxonicotinate:ferredoxin oxidoreductase
Systematic name:
6-oxo-1,4,5,6-tetrahydronicotinate:ferredoxin oxidoreductase

Reaction

Comments:

Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. Other enzymes involved in this pathway are EC 1.17.5.1 (nicotinate dehydrogenase), EC 3.5.2.18 (enamidase), EC 1.1.1.291 (2-hydroxymethylglutarate dehydrogenase), EC 5.4.99.4 (2-methyleneglutarate mutase), EC 5.3.3.6 (methylitaconate Δ-isomerase), EC 4.2.1.85 (dimethylmaleate hydratase) and EC 4.1.3.32 (2,3-dimethylmalate lyase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047595
CAS Registry Number: 9030-84-6
UniProtKB/Swiss-Prot:

References

  1. Holcenberg, J.S. and Tsai, L.
    Nicotinic acid metabolism. IV. Ferredoxin-dependent reduction of 6-hydroxynicotinic acid to 6-oxo-1,4,5,6-tetrahydronicotinic acid.
    J. Biol. Chem. 244: 1204-1211 (1969). [PMID: 5767303]

[EC 1.3.7.1 created 1972]