EC 1.3.3.9 - Secologanin synthase

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IntEnz Enzyme Nomenclature
EC 1.3.3.9

Names

Accepted name:
secologanin synthase
Systematic name:
loganin:oxygen oxidoreductase (ring-cleaving)

Reaction

Cofactor

Comments:

A heme-thiolate protein (P-450). Secologanin is the precursor of the monoterpenoid indole alkaloids and ipecac alkaloids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00081
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050616
CAS Registry Number: 258339-71-8
UniProtKB/Swiss-Prot:

References

  1. Yamamoto, H., Katano, N., Ooi, A. and Inoue, K.
    Secologanin synthase which catalyzes the oxidative cleavage of loganin into secologanin is a cytochrome P-450.
    Phytochemistry 53: 7-12 (2000). [PMID: 10656401]
  2. Irmler, S., Schröder, G., St-Pierre, B., Crouch, N.P., Hotze, M., Schmidt, J., Strack, D., Matern, U. and Schröder, J.
    Indole alkaloid biosynthesis in Catharanthus roseus: new enzyme activities and identification of cytochrome P-450 CYP72A1 as secologanin synthase.
    Plant J. 24: 797-804 (2000). [PMID: 11135113]
  3. Yamamoto, H., Katano, N., Ooi, Y. and Inoue, K.
    Transformation of loganin and 7-deoxyloganin into secologanin by Lonicera japonica cell suspension cultures.
    Phytochemistry 50: 417-422 (1999).

[EC 1.3.3.9 created 2002]