EC - Acyl-CoA dehydrogenase (NADP+)

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IntEnz Enzyme Nomenclature


Accepted name:
acyl-CoA dehydrogenase (NADP+)
Other names:
2-enoyl-CoA reductase
crotonyl coenzyme A reductase
crotonyl-CoA reductase
dehydrogenase, acyl coenzyme A (nicotinamide adenine dinucleotide phosphate)
enoyl coenzyme A reductase
Systematic name:
acyl-CoA:NADP+ 2-oxidoreductase



The liver enzyme acts on enoyl-CoA derivatives of carbon chain length 4 to 16, with optimum activity on 2-hexenoyl-CoA. In Escherichia coli, cis-specific and trans-specific enzymes exist [EC cis-2-enoyl-CoA reductase (NADPH) and EC trans-2-enoyl-CoA reductase (NADPH)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047616
CAS Registry Number: 37251-07-3


  1. Dommes, V., Luster, W., Cvetanovic, M. and Kunau, W.-H.
    Purification by affinity chromatography of 2,4-dienoyl-CoA reductases from bovine liver and Escherichia coli.
    Eur. J. Biochem. 125: 335-341 (1982). [PMID: 6749495]
  2. Seubert, W., Lamberts, I., Kramer, R. and Ohly, B.
    On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.
    Biochim. Biophys. Acta 164: 498-517 (1968). [PMID: 4387390]

[EC created 1972, modified 1986]